Preclinical & Translational

Kosmoscience offers advanced preclinical and translational biological studies to investigate the safety, efficacy, and mechanisms of action of active ingredients and formulations. Our scientific approach integrates in vitro tests, advanced cellular models, native human tissues, and internationally recognized alternative methods with biological investigations using samples collected from clinical study participants.

Our research platform combines advanced technologies and a highly specialized scientific team to investigate biomarkers, biological pathways, and cellular and tissue responses associated with product safety and performance. From inflammation, photoprotection, and skin barrier function to cellular longevity and skin aging, each study is tailored to the scientific, regulatory, and strategic objectives of the project.

Through Translational Science, we extend biological investigations beyond experimental models to human samples obtained during clinical studies. This approach enables the exploration of molecular and cellular responses, as well as microbiome profiling, helping connect mechanistic evidence with clinical outcomes and providing a more comprehensive understanding of product performance.

Committed to innovation and responsible science, Kosmoscience conducts its studies using advanced non-animal methods and human-relevant biological models to generate reliable scientific evidence aligned with global standards and evolving market requirements.

Preclinical & Translational
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Preclinical & Translational Biological Studies

Cell biology & longevity

  • Cellular aging
  • Senescence
  • Cellular memory (recovery of cellular potential)
  • Mitochondrial function
  • Autophagy
  • DNA damage and protection
  • Glycation

Skin biology & performance

  • Skin hydration
  • Skin barrier function
  • Epidermal differentiation
  • Sensitive skin
  • Skin pigmentation
  • Sebum regulation
  • Extracellular matrix (ECM) integrity

Inflammation, immunity & regeneration

  • Inflammatory signaling
  • Neurogenic inflammation
  • Itch modulation
  • Innate immune defense
  • Tissue repair
  • Wound healing

Photobiology & environmental stress

  • UV, visible light & infrared (IR) protection
  • Oxidative stress
  • Photodamage
  • Pollution-induced stress
  • Antioxidant defense
  • Exposome-related effects

Hair & scalp biology

  • Hair growth signaling
  • Hair longevity
  • Follicular biology
  • Androgenic pathways
  • Hair nutrition
  • Scalp health and homeostasis

Translational biomarker studies

  • Analysis of biological samples collected during clinical studies
  • Molecular biomarkers
  • Protein expression
  • Tissue biomarkers
  • Microbiome profiling
  • Mechanistic–clinical correlations

Skin permeation & biodistribution

  • Percutaneous absorption (OECD 428)
  • Epidermal and dermal distribution
  • Analytical quantification

Predictive & advanced safety assessment

  • Skin & eye safety (irritation/corrosion)
  • Sensitization
  • Phototoxicity
  • Mutagenicity
  • Systemic toxicity screening
  • Biocompatibility
  • Complementary safety assessments
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