Neuromodulatory and Anti-inflammatory ingredient for sensitive skin: in vitro assessment.

Author: Samara Eberlin

Published at: October 08, 2014

Inflammation & Allergy Drug Targets 13(3), 191-8, 2014.
DOI: http://dx.doi.org/10.2174/1871528113666140616112708
Costa A, Eberlin S, Polettini AJ, Pereira AFC, Pereira CS, Ferreira NMC, Dolis E, Torloni LBO.

The manifestation of sensitive skin occurs as a consequence of increased permeability of the stratum corneum, as well as the involvement of the neuro-immune-endocrine system. In this study, we evaluated the effects of an active ingredient, SensC, on the production of neuropeptides substance P (SP), enkephalin, and β-endorphin; eicosanoids prostaglandin E2 (PGE2) and leukotriene B4 (LTB4); histamine, TRPV1, and envelope proteins filaggrin and involucrin, using an in vitro model of human cell culture. Our results demonstrated that treatment of keratinocyte cultures with SensC prevented the increase of all evaluated inflammatory mediators induced by interleukin-1 alpha (IL-1α). Similarly, SensC provided a decrease in the synthesis of TRPV1. Regarding the synthesis of envelope proteins, SensC promoted increases in filaggrin and involucrin levels compared to the control group. Considering the absence of appropriate treatment, the availability of ingredients such as SensC, with anti-inflammatory and protective barrier properties, can be a significant tool for preventing neurosensorial symptoms associated with sensitive skin.